• Our synthetic VLPs are formed by triggered assembly of modified protein.

• Have significant potential due to easily modifiable exterior and interior surfaces of the cage structure.

• Properties of the synthetic VLPs allows for encapsulation of multiple different therapeutic molecules including proteins, oligonucleotides, small molecules and their transport and precise targeting to desired targets in vivo.

• We believe that our structures provide modification and engineering capabilities superior to current lipid or dendrimer based technologies. As a result, we expect that these protein cages will have improved biodistribution, targeting and pharmacokinetics compared to currently available delivery platforms.

• nCage’s platform is the only artificial protein cage or synthetic VLP that has programmable opening resulting in controlled release of biological cargo in response to external stimuli. For example they can be triggered to break apart on addition of cellular reducing agents.