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Protein cages are synthetic virus-like particles (VLPs), that can be used to display biological material on their surface, or transport molecules such as nucleic acids or proteins into the interior of the cell.
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TRAP-Cages are protein cages formed from rings of the bacterial TRAP protein. Protein cages are synthetic viral like particles that can act like a virus to display biological material on their surface, or transport nucleic acid, or proteins into the interior of the cell.
SYNTHETIC VIRAL LIKE PARTICLES
• nCage’s TRAP-cage Artificial Protein Cages are formed by multiple copies of modified or de novo protein components designed to form stable, hollow protein shapes.
• nCage’s platform is based on the bacterial TRAP protein.
•Protein cages are akin to synthetic viral particles (but without nucleic material).
• The outside of cages can be used to mount protein or other biologic material on the outside.
• Proteins can be mounted in repeating arrays mimicking the patterns and structures found in nature.
PROGRAMMABLE OPENING
• A unique feature of theTRAP-cage platform is programmable opening and closing of the cages.
• Therefore, cargo can be loaded into the interior of the cages and be released inside cells.
• Cargo can be proteins, peptides, nucleic acids or small molecule drugs.
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